Vanderbilt vs Missouri Prediction, Picks & Odds | 2026

how_to_reg Who will win Vanderbilt vs Missouri today: Vanderbilt (-130)

Vanderbilt enters this matchup with a blistering 7-1 record, having won five straight games. Their only loss came on the road against a top-10 opponent, and they’ve been particularly strong at FirstBank Stadium, where they’ve covered the spread in four of five home games this season. The Commodores’ defence has been the story, allowing just 17 points per game over their last three outings.

Missouri, meanwhile, comes in at 6-2 but has shown fragility away from home. The Tigers have lost two of their last three road games, and their offence has averaged only 19 points in those contests. In the most recent meeting between these teams — a 17-10 Vanderbilt win in Nashville — the Commodores’ defence smothered Missouri’s attack, forcing three turnovers.

The head-to-head history favours Missouri 12-5-1 all-time, but Vanderbilt has won the last two matchups in Nashville, including a 17-10 victory in 2024. With the Commodores playing with confidence and Missouri’s road struggles well-documented, backing Vanderbilt on the moneyline at -130 is the sharp play.

trending_up Vanderbilt vs Missouri Over/Under pick: Under 45.5 (-110)

The under has hit in four of Vanderbilt’s last six games, and in three of Missouri’s last four road contests. The Commodores’ defence ranks in the top 25 nationally in yards allowed per play, while Missouri’s offence has been inconsistent on the road, averaging just 21 points per game away from home.

The last meeting between these teams in Nashville finished 17-10, well under the total. Both defences are battle-tested, and with the game expected to be played in typical mid-October conditions in Nashville — cool, with potential for wind — scoring opportunities could be limited. The Under 45.5 is a strong value play.

payments Vanderbilt vs Missouri odds

The market opened with Vanderbilt as a 2.5-point favourite at FanDuel, and we’ve seen slight movement toward the Commodores as early money came in. The moneyline has shortened from -120 to -130, indicating sharp support for the home side. The total has held steady at 45.5, with the under attracting 58% of early bets.

query_stats Vanderbilt vs Missouri trend to know

Vanderbilt has covered the spread in four of its last five home games, and the under has hit in four of its last six overall. Missouri is 2-5 ATS in its last seven road games, and the under has hit in three of its last four road contests. In head-to-head play, the home team has won and covered the spread in four of the last five meetings.

tv How to watch Vanderbilt vs Missouri and game info

sports_football Vanderbilt

Vanderbilt enters this game with a 7-1 record, sitting at the top of the SEC standings. The Commodores have been a revelation this season, powered by a stifling defence that allows just 16.3 points per game. Offensively, they’ve been efficient, averaging 28.4 points per game while committing only six turnovers all season.

At home, Vanderbilt is 4-1 straight up and 3-2 ATS. Their only blemish was a narrow loss to a top-10 opponent, but they’ve responded with three straight wins, including a dominant 31-14 victory over a ranked opponent. The Commodores’ run game has been particularly effective, averaging 4.7 yards per carry.

Head coach Clark Lea has instilled a tough, disciplined culture, and it shows in Vanderbilt’s ability to win close games. They’re 4-1 in games decided by one possession this season, a key indicator of a team that knows how to finish.

sports_football Missouri

Missouri arrives in Nashville with a 6-2 record, but their two losses have come away from home. The Tigers’ offence has been inconsistent on the road, averaging just 21.3 points per game compared to 34.1 at home. Quarterback Brady Cook has been solid but has struggled under pressure, throwing five of his seven interceptions in road games.

Defensively, Missouri has been solid, allowing 22.1 points per game, but they’ve struggled against physical run games. Vanderbilt’s commitment to the ground game could exploit that weakness. The Tigers are 2-3 ATS on the road this season and have lost two of their last three away games.

Head coach Eli Drinkwitz has a 12-5-1 record all-time against Vanderbilt, but the Tigers have lost two straight in Nashville. Missouri’s offence will need to find consistency against a Vanderbilt defence that has been one of the best in the SEC.

medical_services Vanderbilt vs Missouri latest injuries

No major injury concerns have been reported for either team ahead of this matchup. Both sides are expected to be at full strength, with no key players listed on the injury report as of game week.

Vanderbilt has been fortunate with health all season, starting the same offensive line in every game. Missouri has also avoided significant injuries, with all key skill-position players available.

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